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Pancreatic islet expression profiling in diabetes-prone C57BLKS/J mice reveals transcriptional differences contributed by DBA loci, including Plagl1 and Nnt

Abraham A Anderson1*, Joan Helmering2, Todd Juan3, Chi-Ming Li3, Jocelyn McCormick2, Melissa Graham2, Daniel M Baker4, Michael A Damore4, Murielle M Véniant2 and David J Lloyd2

Author Affiliations

1 Department of Computational Biology, Amgen Inc., One Amgen Center Dr, Thousand Oaks, CA 91320, USA

2 Department of Metabolic Disorders, Amgen Inc., One Amgen Center Dr, Thousand Oaks, CA 91320, USA

3 Department of Protein Sciences, Amgen Inc., One Amgen Center Dr, Thousand Oaks, CA 91320, USA

4 Department of Molecular Sciences, Amgen Inc., One Amgen Center Dr, Thousand Oaks, CA 91320, USA

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PathoGenetics 2009, 2:1 doi:10.1186/1755-8417-2-1

Published: 22 January 2009

Additional files

Additional file 1:

Supplementary data. Figure showing location of the probes from the islet expression profiling compared to the genomic location of the contributing genomes. Table showing differences in gene expression between genomic regions (DBA, B6, Other, Unmapped) at the whole genome and chromosomal levels.

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