Abnormal autophagy, ubiquitination, inflammation and apoptosis are dependent upon lysosomal storage and are useful biomarkers of mucopolysaccharidosis VI

doi:10.1186/1755-8417-2-4

PathoGenetics

Volume 2

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Abnormal autophagy, ubiquitination, inflammation and apoptosis are dependent upon lysosomal storage and are useful biomarkers of mucopolysaccharidosis VI

Alessandra Tessitore¹, Marinella Pirozzi¹ and Alberto Auricchio¹^,2

¹Telethon Institute of Genetics and Medicine (TIGEM), Naples, Italy

²Medical Genetics, Department of Pediatrics, 'Federico II' University, Naples, Italy

PathoGenetics 2009, 2:4doi:10.1186/1755-8417-2-4


Published:	16 June 2009

Additional files

Additional file 1:

Epidermal Growth Factor (EGF)/EGF Receptor (EGFR) turnover in NR fibroblasts. Normal skin fibroblasts were loaded with LysoTracker (red) and EGF (green) to follow the EGF/EGFR turnover via lysosomal degradation. Image sequences were recorded at one frame per 15 min, played at 3 frames/sec, and cover 20 sec (5 h). Time is indicated in the upper left corner and is hours:minutes:seconds. Scale bar = 20 μm.

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Additional file 2:

Epidermal Growth Factor (EGF)/EGF Receptor (EGFR) turnover in MPS VI fibroblasts. MPS VI skin fibroblasts were loaded with LysoTracker (red) and EGF (green) to follow the EGF/EGFR turnover via lysosomal degradation. Image sequences were recorded at one frame per 15 min, played at 3 frames/sec, and cover 20 sec (9 h). Time is indicated in the upper left corner and is hours:minutes:seconds. Scale bar = 20 μm.

Format: MOV Size: 4.2MB Download file

Playing the movie within this page requires QuickTime and JavaScript. Read more